じん細胞カルシウム代謝に対する１α‐ヒドロキシコレカルシフェロールの影響

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  • Effect of 1α-hydroxycholecalciferol on cellular calcium metabolism of kidney cortex
  • ジン サイボウ カルシウム タイシャ ニ タイスル 1アルファ Hydroxy

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Rats were provided a normal laboratory diet or a low Ca-vitamin D-deficient diet. After the administration of 1α-hydroxycholecalciferol, mitochondria, microsomes and slices were prepared from kidney cortex of both control and treated rats. When 1α-hydroxycholecalciferol was given to normal and low Ca·vitamin D-deficient rats, Ca accumulation in mitochondria was stimulated during 30 minutes and the high calcium content was maintained at the subsequent incubation. There was a significant decrease of mitochondrial Ca2+-ATPase and Mg2+-ATPase activities with low Ca·vitamin D depletion, but both enzyme activities were restored by 1α-hydroxycholecalciferol treatment of the depleted rats. Ca2+-ATPase and Mg2+-ATPase activities of microsomes were not altered with the administration of 1α-hydroxycholecalciferol. In contrast to results of mitochondrial Ca transport, changes in Ca influx and efflux of slices were not significant in response to the treatment of low Ca·vitamin D-deficient rats with 1α-hydroxycholecalciferol. The results of the present study suggest that 1αhydroxycholecalciferol plays a role in the process of Ca accumulation and ATP hydrolysis of mitochondria in kidney cortex.

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