２級アミンＭｅｃａｍｙｌａｍｉｎｅおよび３級アミンＰｅｍｐｉｄｉｎｅのネコせき髄反対に対する作用

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タイトル別名
  • Effects of mecamylamine and pempidine, secondary and tertiary amines, on the spinal reflex of cats
  • 2キュウ アミン Mecamylamine オヨビ 3キュウ アミン Pemp

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The ganglionic blocking effects of the secondary and tertiary amines, mecamylamine and pempidine, on the spinal reflex of cats of both sexes were investigated. These blocking effects were then compared with findings in the quaternary ammonium compounds such as tetraethylammonium (TEA) and decamethonium (CIO). Mecamylamine (5 mg/kg) and pempidine (1 mg/kg) inhibited spinal reflex potentials such as the monosynaptic reflex (MSR), the polysynaptic reflex (PSR) and the dorsal root reflex (DRR). Maximal inhibition occurred 40 min after intravenous administration these drugs. In the case of mecamylamine, the inhibited potentials recovered gradually after reaching the maximum inhibition. However, the inhibitory effect of pempidine was prolonged, and recovery of the potentials did not occur for 60 min or longer. Although 10 mg/kg of CIO and 0.025 mg/kg of nicotine transiently inhibited the MSR and PSR, these compounds had no effect on the DRR. TEA produced prolonged inhibition of the MSR and PSR, and slightly enhanced the DRR. These results demonstrated the differences in DRR responses to secondary and tertiary amines, and quaternary ammoniums.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 77 (5), 469-476, 1981

    公益社団法人 日本薬理学会

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