Cytoprotective activity of tiquizium bromide (HSR-902) and its mechanism.
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- MORIKAWA Kouji
- Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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- ARATANI Takayuki
- Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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- MIZUTANI Fujie
- Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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- KATO Hideo
- Research Laboratories, Hokuriku Seiyaku Co., Ltd.
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- ITO Yasuo
- Research Laboratories, Hokuriku Seiyaku Co., Ltd.
Bibliographic Information
- Other Title
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- Tiquizium bromide(HSR‐902)の急性胃粘膜損傷に対するCytoprotective作用とその機序
- Tiquizium bromide HSR 902 ノ キュウセイ イ ネンマ
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Abstract
The effects of HSR-902, an antimuscarinic agent, on acute gastric mucosal lesions induced by various necrotizing agents, gastric mucus secretion and gastric HCO3- secretion in rats were compared with those of pirenzepine•2HCl (pirenzepine), an antiulcer agent. 1) HSR-902 (10 ?? 100 mg/kg), given orally, dose-dependently prevented the gastric mucosal lesions induced by ethanol-HCl (60% ethanol in 150 mM HCl), aspirin-HCl (150 mg/kg of aspirin in 150 mM HCl), 0.6 N HCl and 0.2 N NaOH; and the cytoprotective effects of HSR-902 were almost equal or somewhat more potent than those of pirenzepine. 2) HSR-902 (30 mg/kg, p.o.), like pirenzepine, increased the alcian blue binding to gastric mucosa and both hexosamine and N-acetylneuramic acid in gastric juice and reversed the decrease of alcian blue binding to gastric mucosa in water-immersion stress. 3) HSR-902 (30 mg/kg, p.o.), unlike pirenzepine and atropine sulfate, increased the gastric HC03- secretion in the pylorus-ligated preparations. 4) The cytoprotective effect of HSR-902 (30 mg/kg, p.o.), when examined using gastric mucosal lesion induced by aspirin-HCl, was not abolished by the pretreatment with indomethacin (10 mg/kg, s.c.) or N-ethylmaleimide (10 mg/kg, s.c.). 5) HSR-902 (30 mg/kg, p.o.) did not influence the gastric mucosal potential difference. These results suggest that HSR-902 is a promising drug for the treatment of gastritis and peptic ulcers.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 90 (5), 285-293, 1987
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271127936
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- NII Article ID
- 130000759426
- 30034986368
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- NII Book ID
- AN00198335
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- COI
- 1:CAS:528:DyaL1cXjtFKqsQ%3D%3D
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3161511
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- PubMed
- 2895054
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed