書誌事項
- タイトル別名
-
- Pharmacological studies on Y-8894. III Its effect on the abnormal electrocorticogram induced by destruction of internal capsule.
- Y-8894 ノ ヤクリガクテキ ケンキュウ 3 ラット ナイホウ ハカイ ユ
この論文をさがす
抄録
The effect of Y-8894 on the abnormal electrocorticogram (ECoG) of alcuronium-immobilized rats, induced by destruction of the internal capsule with heat, was compared with that produced by imipramine, amantadine and Ca-hopantenate. ECoG power in the delta+ theta (1 ?? 7 Hz), alpha (7.5 ?? 12.5 Hz) and beta (13 ?? 30 Hz) bands was used as an index. Delta+theta power increased following destruction of the internal capsule with heat. The increased delta+theta power (abnormal ECoG) lasted for 60 min following the injection of saline at 60°C for 3 min. Y-8894 (0.1 ?? 1 mg/kg, i.v.) apparently improved the abnormal ECoG dose-dependently by significantly reducing the increased delta+theta power. Similar results were obtained with amantadine (10 mg/kg, i.v.), but its potency was weaker than that of Y-8894. Imipramine (1 mg/kg, i.v.) and Ca-hopantenate (30 mg/kg, i.v.), however, both failed to modify the abnormal ECoG. All drugs, except Ca-hopantenate, decreased the magnitudes of the alpha and beta bands. The above results suggest that Y-8894 may be effective in ameliorating cerebral dysfunction induced experimentally by the lesion of the internal capsule.
収録刊行物
-
- 日本薬理学雑誌
-
日本薬理学雑誌 88 (4), 289-297, 1986
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204273510400
-
- NII論文ID
- 130000759582
-
- NII書誌ID
- AN00198335
-
- COI
- 1:CAS:528:DyaL28XmtVeju7w%3D
-
- ISSN
- 13478397
- 00155691
-
- NDL書誌ID
- 3099185
-
- PubMed
- 3491778
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可