ＫＷ‐３０４９（新規Ｄｉｈｙｄｒｏｐｙｒｉｄｉｎｅ‐ｔｙｐｅＣａきっ抗剤）の心臓に対する電気生理学的作用

• 吉竹 郁文

  協和発酵工業(株)医薬研究所

• 久保 和博

  協和発酵工業(株)医薬研究所

• 池田 信男

  中日病院内科

• 児玉 逸雄

  名古屋大学環境医学研究所呼吸循環部門

• 外山 淳治

  名古屋大学環境医学研究所呼吸循環部門

• 山田 和生

  名鉄病院

書誌事項

タイトル別名

• Electrophysiological effects of KW-3049, a novel dihydropyridine type Ca antagonist, on isolated rabbit hearts, sinus nodal tissues and guinea-pig ventricular muscles.
• KW-3049 シンキ Dihydropyridine type Ca キッコ

抄録

Effects of KW-3049 on electrophysiological properties of the heart were examined using Langendorff-perfused hearts and superfused sinus nodal tissues of rabbits and superfused guinea-pig ventricular muscles. In rabbit hearts, KW-3049 at concentrations above 10^-7 M caused a dose-related prolongation of atrio-His bundle conduction time (AH), whereas His bundle-ventricular conduction time (HV) was unaffected. In spontaneously firing rabbit sinus nodal tissues, KW-3049 at concentrations above 10^-8 M prolonged cycle length significantly. At 10^-6 M, amplitude and the maximum upstroke velocity of sinus nodal action potential were decreased as well. In normally polarized guinea-pig ventricular muscles under 4 mM [K⁺]₀, KW-3049 at concentrations above 10^-6 M shortened the action potential duration without affecting the resting membrane potential and the maximum upstroke velocity of action potential (V_max) . The V_max of slow action potentials induced by isoproterenol at 10^-7 M was inhibited significantly by additional application of KW-3049 at concentrations above 10^-9 M. At above 10^-8 M, the amplitude and duration of slow action potentials were reduced significantly. The potency of this slow action potential inhibition by KW-3049 was slightly less than that of nifedipine, while it was 10 to 100 times greater than that of verapamil. Spontaneous activity of ventricular muscles induced by BaCl₂ at 1 mM was abolished completely at 16 min after application of KW-3049 at 10^-7 M. These results suggest that KW-3049 may have a potent and selective inhibitory action on cardiac slow calcium channels.

収録刊行物

• 日本薬理学雑誌

  日本薬理学雑誌 88 (3), 179-187, 1986

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390001204271681920
• NII論文ID: 130000759641
• NII論文ID: 10006060047
• NII書誌ID: AN00198335
• DOI: 10.1254/fpj.88.179
• COI: 1:CAS:528:DyaL28XmtVaqsLg%3D
• ISSN: 13478397
• ISSN: 00155691
• NDL書誌ID: 3099176
• PubMed: 2431981
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3099176
• Web Site: https://search.jamas.or.jp/link/ui/1987058057
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可