健胃生薬複合末のラットの胃液分泌および各種急性胃・十二指腸損傷に対する効果

DOI Web Site PubMed 被引用文献1件

書誌事項

タイトル別名
  • Effects of SM powder, a combined stomatic, on gastric secretion and various gastric and duodenal lesions in rats
  • ケンイ ショウヤク フクゴウマツ ノ ラット ノ イエキ ブンピ オヨビ カクシュ キュウセイ イ ・ ジュウニシチョウ ソンショウ ニ タイスル コウカ

この論文をさがす

抄録

One gram of SM powder consists of 167.8 mg of Coptidis Rhizoma Pulveratum, 250 mg of Cinnamomi Cortex Pulveratus, 67.1 mg of Foeniculi Fractus Pulveratus, 33.6 mg of Caryophylli Flos Pulveratus, 82.1 mg of Zingiberis Rhizoma Pulveratus, 3.4 mg of Zanthoxyli Fructus Pulveratus, and 396 mg of Glycyrrhizae Radix Pulberata. SM powder (2 g/kg, i.d.) significantly inhibited gastric secretion in pylorus-ligated rats and the development of Shay ulcers and indomethacin-induced gastric lesions. The mechanism of the anti-lesion activity of SM powder appears to be due to its antisecretory effect. SM powder also markedly inhibited ethanol or NaOH-induced gastric lesions at doses (30 or 100 mg/kg) which had little effect on gastric secretion. SM powder appears to have a cytoprotective activity which is unrelated to endogenous prostaglandin. However, SM powder had no effect on water-immersion stress or aspirin-induced gastric lesions and mepirizole-induced duodenal ulcers. Gentiana Radix Pulverata, used as a reference stomatic, had also an antisecretory effect and anti-lesion activity on Shay ulcers, aspirin-, ethanol and NaOH-induced gastric lesions. However, it had no effect on water-immersion stress- or indomethacin-induced gastric lesions and mepirizole-induced duodenal ulcers.

収録刊行物

  • 日本薬理学雑誌

    日本薬理学雑誌 81 (4), 285-294, 1983

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ