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- 猪口 貞樹
- 東海大学医学部救急医学, 神奈川科学技術アカデミー
書誌事項
- タイトル別名
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- Human Skin Regenerated on Immunodeficient Mice after Transplantation of Cultured Human Skin Cells. Human Skin Model.
抄録
It has been known that human epidermal keratinocytes can be propagated in vitro and transplanted onto immunodeficient mice. However, the regenerated human epidermis like tissue is rarely retained for a long period. These tissues also lack Langerhans cells.<BR>We show here that co-transplantation of human dermal fibroblasts facilitates the long term maintenance of mature epidermal structures reorganized after xenotransplantation of cultured human keratinocytes. These reorganized human skins on immunodeficient mice are highly reproducible. Furthermore, when human bone marrow derived hematopoietic progenitor cells are co-transplanted with skin cells, repopulation of Langerhans cells in the reorganized epidermis are observed.<BR>We consider that the reorganized human skins on immunodeficient mice are suitable to use as human skin model in vivo.
収録刊行物
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- 日本疾患モデル学会記録
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日本疾患モデル学会記録 13 24-25, 1997
公益社団法人 日本実験動物学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679350079616
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- NII論文ID
- 130000760733
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- ISSN
- 18844197
- 09188991
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可