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- TERASAWA Michio
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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- IMAYOSHI Tomonori
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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- MARUYAMA Yutaka
- Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd.
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- ABE Chiyuki
- Department of Internal Medicine, School of Medicine, Juntendo University
Bibliographic Information
- Other Title
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- Traxanox sodiumの炎症反応に対する作用
- Traxanox sodium ノ エンショウ ハンノウ ニ タイスル サヨウ
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Abstract
Traxanox was inactive against classic acute and subacute inflammation models such as carrageenin paw edema, UV erythema, 6-hr Evans blue-carrageenin (E-C) pleurisy and cotton pellet granuloma formation, and it failed to inhibit the production of prostaglandin E2 and a slow reacting substance from rat peritoneal leucocytes which phagocytize killed bacteria in vitro. On the other hand, traxanox inhibited the anaphylactoid reaction and decreased the pleural fluid in 24-hr E-C pleurisy. Traxanox (100 mg/kg, p.o.) also showed a tendency to suppress dextran edema and cotton pellet granuloma formation in adjuvant arthritis (AA) in rats. In experimental models of delayed type hypersensitivity (DTH), traxanox (100 mg/kg, p.o.) inhibited the accumulation of the exudate and the leucocyte migration in B. pertussis-induced pleurisy in rats. Traxanox (50 mg/kg) did not show any effect on AA in Lewis rats when administered orally for 21 days after the adjuvant inoculation, but the combined administration of traxanox with hydrocortisone (10 mg/kg, p.o.) or indomethacin (0.25 mg/kg, p.o.) resulted in a synergistic inhibition of AA. When the administration of traxanox was started 21 days before the adjuvant inoculation, it inhibited AA in a dose-dependent manner (50 ?? 100 mg/kg, p.o.). On the other hand, traxanox (100 mg/kg, p.o.) enhanced the concanavalin A-induced DTH-like skin reaction in guinea pigs. These results indicate that the mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis.
Journal
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- Folia Pharmacologica Japonica
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Folia Pharmacologica Japonica 86 (5), 329-340, 1985
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204271426304
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- NII Article ID
- 130000760857
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- NII Book ID
- AN00198335
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- ISSN
- 13478397
- 00155691
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- NDL BIB ID
- 3062080
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- PubMed
- 2867959
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed