書誌事項
- タイトル別名
-
- The effects of various drugs on the binding site of bilirubin in serum albumin
- ケッセイ アルブミン ノ ビリルビン ケツゴウ ブイ ニ タイスル ヤクブツ
この論文をさがす
抄録
In the presence of various drugs, the concentration of free bilirubin which was released from the first binding site of bilirubin in serum albumin was evaluated, using a sensitive method based on static fluorescence quenching of dansyl serum albumin. Bilirubin bound to human serum albumin more strongly than to bovine serum albumin. Non-steroidal anti-inflammatory drugs, fenamates and allylphenyl propionic acids, affected the bilirubin-serum albumin interaction. Flufenamic acid and ketoprofen released bilirubin from human serum albumin. The bilirubin bound to the serum albumin was not influenced by the presence of indomethacin, but clidanac strongly dissociated bilirubin from the bilirubin-serum albumin complex. Sulfa-drugs, antibiotics, steroidal agents, warfarine, tolubutamide and phenytoin showed no significant effects on the bilirubin-serum albumin interaction. The fluorescence quenching method may be useful to evaluate the interaction of drug-bilirubin-serum albumin.
収録刊行物
-
- 日本薬理学雑誌
-
日本薬理学雑誌 83 (1), 79-83, 1984
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679250108928
-
- NII論文ID
- 130000760918
-
- NII書誌ID
- AN00198335
-
- ISSN
- 13478397
- 00155691
-
- NDL書誌ID
- 2977154
-
- PubMed
- 6714852
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可