Effects of temperature on norepinephrine-induced sinus acceleration and overdrive suppresion in the isolated dog atrium

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  • Effects of Temperature on Norepinephrine-Induced Sinus Acceleration and Overdrive Suppression in the Isolated Dog Atrium
  • Effects of temperature on norepinephrin

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Using an isolated, blood-perfused atrium preparation, the effects of temperature on SA nodal pacemaker activity were investigated in 9 preparations. The PP interval decreased as temperature was raised. Regular sinus rhythm and atrial contraction were maintained above approximately 26°C. Below 26°C, sinus depolarization still showed a regular rate, although atrial contractions had ceased. At about 24°C, atrial rhythm became irregular. Below 20°C, atrial depolarization disappeared.<br>Chronotropic responses to norepinephrine were suppressed at decreased temperatures, not only with respect to maximum PP shortening but also to the threshold dose for inducing sinus acceleration.<br>Overdrive suppression was not influenced significantly by decreasing temperature.<br>These results indicate that a temperature decrease causes suppression of SA nodal pacemaker activity, although the SA node continues to function regularly until about 25°C.

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