Studies on the effects of hyperkalemia on serum and myocardial digoxin concentration in dogs.
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- KORI Yoshitaka
- First Department of Internal Medicine, Kobe University School of Medicine
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- FUJITANI Kazuhiro
- First Department of Internal Medicine, Kobe University School of Medicine
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- NAGAI Isamu
- First Department of Internal Medicine, Kobe University School of Medicine
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抄録
The effects of hyperkalemia on serum and myocardial digoxin (DX) concentration was studied in conjunction with hemodynamic changes in 31 normal dogs. The myocardial DX concentration in the hyperkalemic (HK) group was significantly lower than that in normokalemic (NK) group, despite a significantly higher serum DX concentration in the HK group. In the HK group, the myocardial sodium concentration was significantly lower than in the NK group. Coincident with these biochemical changes, no increase of LV max dP/dt after DX administration was observed in the HK group. These results suggest that there might be competitive antagonism between myocardial uptake of potassium and DX.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 24 (6), 947-959, 1983
International Heart Journal刊行会