Cellular Mechanisms of Cardiovascular Hypertrophy in Spontaneously Hypertensive Rats (SHR) and Their Modification

• Yamori Yukio

  Department of Pathology, Shimane Medical University

• Igawa Takehiro

  Department of Pathology, Shimane Medical University

• Kanbe Toshimi

  Department of Pathology, Shimane Medical University

• Tagami Motoki

  Sanraku Hospital

• Kihara Masahiro

  Department of Pathology, Shimane Medical University

• Nara Yasuo

  Department of Pathology, Shimane Medical University

• Fujiwara Keigo

  Department of Pathology, Shimane Medical University

• Horie Ryoichi

  Department of Pathology, Shimane Medical University

抄録

Major cellular abnormalities in the cardiovascular system of SHR detected up to the present "in vitro" under tissue culture condition were accelerated proliferation and deviated ionic transport of vascular smooth muscle cells (SMC). The experimental modification of these abnormalities 'in vitro' and 'in vivo' indicated that neural innervation and/or catecholamines as well as sodium and nutritional conditions might substantially affect the basic process of hypertension-induced vascular changes, hypertrophy and/or hyperplasia of medial SMC which further raised the peripheral vascular resistance in hypertension.

収録刊行物

• Ｊａｐａｎｅｓｅ　Ｈｅａｒｔ　Ｊｏｕｒｎａｌ

  Ｊａｐａｎｅｓｅ　Ｈｅａｒｔ　Ｊｏｕｒｎａｌ 25 (5), 823-826, 1984

  International Heart Journal刊行会

キーワード

• Cardiology and Cardiovascular Medicine

詳細情報

• CRID: 1390001205038940800
• NII論文ID: 130000764340
• DOI: 10.1536/ihj.25.823
• ISSN: 1348673X
• ISSN: 00214868
• Web Site: http://www.jstage.jst.go.jp/article/ihj1960/25/5/25_5_823/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可