Application of the systolic stiffness concept to assess myocardial function in developing hypertension.

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  • AOYAGI Teruhiko
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital New England Regional Primate Research Center
  • FUJII Alan M.
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital New England Regional Primate Research Center
  • GELPI Ricardo J.
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital New England Regional Primate Research Center
  • HITTINGER Luc
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital New England Regional Primate Research Center
  • CROCKER Valerie M.
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital New England Regional Primate Research Center
  • MIRSKY Israel
    Department of Medicine, Harvard Medical School, Brigham and Women's Hospital New England Regional Primate Research Center

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The concept of end-systolic myocardial stiffness permits the quantification of preload effects on fiber shortening and changes in the slope (max Eav) of the end-systolic stress-strain relation, which, if linear, reflect changes in the inotropic state. As an application of this new concept, the end-systolic stress-strain and shortening-afterload relations were evaluated on the basis of data from dogs studied during development of perinephritic hypertension. End-systolic stress-strain relations were linear before and 2 weeks after the induction of hypertension and the end-systolic pressure-diameter relations were not always linear. The shortening-afterload relations obtained directly from raw data points displayed enhanced contractility in the hypertensive state under betaadrenergic receptor blockade. However, the preload-corrected shortening-afterload relations demonstrated that contractility was unchanged in hypertension. Hypertensive hearts operated at higher preload than normotensive hearts at any afterload levels. This discrepancy between the conventional method without preload-correction and the preloadcorrected analysis indicates the importance of preload- correction on shortening-afterload relations in hypertension.

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