Q-T Interval Prolongation in Liver Cirrhosis. Reversibility after Orthotopic Liver Transplantation.
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- FINUCCI Gianfranco
- Department of Clinical Medicine, University of Padua
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- LUNARDI Federico
- Department of Clinical Medicine, University of Padua
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- SACERDOTI David
- Department of Clinical Medicine, University of Padua
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- VOLPIN Roberta
- Department of Clinical Medicine, University of Padua
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- BORTOLUZZI Andrea
- Department of Clinical Medicine, University of Padua
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- BOMBONATO Giancarlo
- Department of Clinical Medicine, University of Padua
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- ANGELI Paolo
- Department of Clinical Medicine, University of Padua
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- GATTA Angelo
- Department of Clinical Medicine, University of Padua
書誌事項
- タイトル別名
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- Reversibility after Orthotopic Liver Transplantation
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抄録
The aim of this work was to study the prevalence of Q-T prolongation in patients with liver cirrhosis and the modifications of the Q-T interval after liver transplantation. Q-T interval corrected for heart rate (QTc) and dispersion of Q-T interval were evaluated in 75 cirrhotic patients and in 24 controls by means of a 12-lead electrocardiogram. In addition, 15 patients were evaluated before and after liver transplantation. Forty-five patients (60%) had a prolonged Q-Tc. Compared with controls, both patients with alcoholic and non alcoholic cirrhosis had increased Q-Tc (414±28 msec1/2, 463±31 and 444±32 respectively; p<0.001 and <0.001); Q-Tc was significantly higher in alcoholic than in non-alcoholic cirrhosis (p<0.02). Q-T dispersion was normal in cirrhotics. No correlation was found between Q-Tc interval and severity of the cirrhosis, haemodynamic variables (stroke volume, cardiac output) and s-calcium and potassium concentrations. After transplantation, Q-Tc decreased significantly (415±26 msec1/2 vs 449±31; p<0.0001) returning to the values of the normal subjects, but no modification of the Q-T dispersion was observed. These data show that 1) prolongation of Q-T interval is frequent in cirrhosis, being higher in alcoholic than in non-alcoholic cirrhosis, 2) is not related to the severity of the disease, and 3) is reversible after transplantation.
収録刊行物
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- Japanese Heart Journal
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Japanese Heart Journal 39 (3), 321-329, 1998
International Heart Journal刊行会