Systemic Lupus Erythematosus Complicated by Cytomegalovirus-Induced Hemophagocytic Syndrome and Colitis.

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  • SAKAMOTO Osamu
    The First Department of Internal Medicine, Kumamoto University School of Medicine
  • ANDO Makoto
    The First Department of Internal Medicine, Kumamoto University School of Medicine
  • YOSHIMATSU Shinichi
    The First Department of Internal Medicine, Kumamoto University School of Medicine
  • KOHROGI Hirotsugu
    The First Department of Internal Medicine, Kumamoto University School of Medicine
  • SUGA Moritaka
    The First Department of Internal Medicine, Kumamoto University School of Medicine
  • ANDO Masayuki
    The First Department of Internal Medicine, Kumamoto University School of Medicine

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Here, we report a case of systemic lupus erythematosus (SLE) complicated by cytomegalovirus (CMV)-induced hemophagocytic syndrome (HPS) and colitis. A 44-year-old woman with SLE was treated with corticosteroid and cyclophosphamide for lupus nephritis. Although her lupus nephritis improved, fever, progressive pancytopenia and intestinal bleeding were observed. A bone marrow aspiration showed an increase in mature histiocytes with hemophagocytosis. In addition, a colonoscopy showed hemorrhagic colitis with ulcer and the biopsy specimen from the colon revealed typical CMV cells with CMV inclusions confirmed by immunohistochemistry. Furthermore, a large number of CMV antigen-positive leukocytes was detected, suggesting an active CMV infection. CMV infection is serious in compromised hosts. Therefore clinicians should be aware of the clinical settings in which this infection can arise and the target organs potentially affected in order to initiate the appropriate intervention.<br>(Internal Medicine 41:151-155, 2002)

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  • Internal Medicine

    Internal Medicine 41 (2), 151-155, 2002

    一般社団法人 日本内科学会

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