On Vascular Permeability Factor from the Kidney Cortex

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  • MURAKAMI Mototaka
    Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • SEKIMOTO Hiroshi
    Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • YASUDA Yoshiaki
    Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • MASUDA Sumio
    Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • YASUMURA Akiyoshi
    Second Department of Internal Medicine, School of Medicine, Kanazawa University
  • NAGAI Tadayuki
    Second Department of Internal Medicine, School of Medicine, Kanazawa University

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(1) The vascular permeability factor is present in the renal cortex.This factor has no pressor activity and is quite different from renin. <br>(2) The vascular permeability factor has the characteristics of a protein. Immunoelectrophoretic study reveals a single precipitation line. <br>(3) Administration of the vascular permeability factor to mice causes cerebral hemorrhage. <br>(4) Rabbits subjected to renal ischemia develop cerebral hemorrhages but are provided protection against it through lanolin feeding. <br>(5) Some evidence is presented indicating that the renal vascular permeability factor plays an important role in the development of vascular lesions.

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