Incidence of Anti-Mouse IgG in normal subjects and Patients with Autoimmune Thyroid Disease.

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  • IITAKA Makoto
    the Fourth Department of Internal Medicine, Saitama Medical School
  • KITAHAMA Shinji
    the Fourth Department of Internal Medicine, Saitama Medical School
  • FUKASAWA Nobuhiko
    the Fourth Department of Internal Medicine, Saitama Medical School
  • MIURA Shiro
    the Fourth Department of Internal Medicine, Saitama Medical School
  • KAWAKAMI Yoshito
    the Fourth Department of Internal Medicine, Saitama Medical School
  • SAKURAI Shinichi
    the Fourth Department of Internal Medicine, Saitama Medical School
  • YANAGISAWA Morifumi
    the Fourth Department of Internal Medicine, Saitama Medical School
  • ISHII Jun
    the Fourth Department of Internal Medicine, Saitama Medical School

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Serum antibodies to mouse IgG occasionally interfere with two-site immunometric assays in which mouse monoclonal antibodies are used. We examined the titers of antibodies to mouse IgG in serum samples from normal subjects and patients with autoimmune thyroid disease (AITD) using an enzyme-linked immunosorbent assay. Anti-mouse IgG antibodies were positive in 7/119 patients with Graves' disease (5.9%) and 3/60 patients with Hashimoto's thyroiditis (5.0%). One of the 15 patients with a thyroid neoplasm (6.7%) also had antibodies to mouse IgG, as did 5/60 healthy subjects (8.3%). These antibodies were either of the IgG or IgM class. There was no significant difference in the incidence of positive anti-mouse IgG antibody between normal subjects and patients with AITD. It is important to note this high incidence of antibodies to mouse IgG due to the potential of interference with immunometric assays employing mouse monoclonal antibodies.<br>(Internal Medicine 31 : 984-988, 1992)

収録刊行物

  • Internal Medicine

    Internal Medicine 31 (8), 984-988, 1992

    一般社団法人 日本内科学会

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