Malignant Hyperthermia Caused by Intravenous Lidocaine for Ventricular Arrhythmia.
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- TATSUKAWA Hirotaka
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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- OKUDA Junichi
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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- KONDOH Morihiko
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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- INOUE Miho
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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- TERASHIMA Satoshi
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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- KATOH Shuji
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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- IDA Kazunori
- the Department of Internal Medicine, Murakami Memorial Hospital, Asahi University
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We encountered a case of malignant hyperthermia caused by intravenous lidocaine which had been administered as treatment for a ventricular arrhythmia. The patient, a 72-year-old male, was admitted with chronic renal failure and aortic valvular stenosis. His chronic renal failure progressed, and congestive heart failure developed, and ventricular arrhythmias occurred frequently. For the treatment of these arrhythmias, lidocaine was injected and continuous infusion was started. Despite initial improvement in symptoms and laboratory data following hemofiltration, refractory ventricular tachycardia occurred. The patient was treated with large doses of lidocaine. His body temperature rose to a maximumof 41.7°C, and generalized muscular twitching was observed before he lost consciousness. Serum and urinary myoglobin levels became elevated. This abnormally high fever was relieved only by dantrolene sodium. After we madea diagnosis of malignant hyperthermia and stopped the lidocaine infusion, the high fever resolved quickly. It is important to note that malignant hyperthermia can be caused by lidocaine and amide-linked local anesthetics.<br>(Internal Medicine 31: 1069-1072, 1992)
収録刊行物
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- Internal Medicine
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Internal Medicine 31 (8), 1069-1072, 1992
一般社団法人 日本内科学会
