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- YAMATO Hiroshi
- the Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
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- NAKASHIMA Yasuhide
- the Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
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- NINOMIYA Kenichi
- the Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
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- SAKURAI Shugo
- the Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
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- KUROIWA Akio
- the Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine
抄録
A 53-year-old man was admitted with impairment of breathing following laryngeal edema. Serum levels of CH50 (22 U/ml), C4 (3 mg/dl), C1-INH protein (10.6 mg/dl) and C1-INH activity (LT 25%) were low. Complement study of the patient's family members revealed that he was one of 5 patients in 3 generations with hereditary angioneurotic edema (HANE). Administration of the androgen derivatives Danazol (600 mg/day) and Oxymetholone (30 mg/day) effectively increased serum levels of C1-INH activity and C4. Though eruption and hepatic dysfunction attributable to administration of the drugs appeared, these side effects improved after withdrawal of the drugs. Subsequently, the treatment with Danazol at a low dose (100 mg/day) was resumed, and the patient has had no episodes of edema for the past 3 years. Regarding the familial cases of HANE, fewer than 20 have been reported in Japan.<br>(Internal Medicine 31 : 353-356, 1992)
収録刊行物
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- Internal Medicine
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Internal Medicine 31 (3), 353-356, 1992
一般社団法人 日本内科学会