A Case of Glomerular Lipidosis Accompanied by Familial Combined Hyperlipidemia and Panhypopituitarism.
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- ABE Tomoko
- Department of Medicine, Iwamizawa Municipal General Hospital
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- KONDO Takahito
- The First Department of Medicine, School of Medicine, Hokkaido University
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- SUZUKI Akihiko
- Department of Medicine, Iwamizawa Municipal General Hospital
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- YAMAMOTO Hiroshi
- Department of Medicine, Iwamizawa Municipal General Hospital
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- WATANABE Naoyoshi
- Department of Medicine, Iwamizawa Municipal General Hospital
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- KURODA Rensuke
- Department of Medicine, Iwamizawa Municipal General Hospital
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- FUKAZAWA Yuichiro
- Department of Pathology, Sapporo City General Hospital
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- KAWAKAMI Yoshikazu
- The First Department of Medicine, School of Medicine, Hokkaido University
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抄録
This is a report of a case of glomerular lipidosis with familial combined hyperlipidemia and panhypopituitarism. A 60-yr-old woman was admitted for evaluation of hyponatremia. Administration of hydrocortisone normalized the level of serum Na. A pituitary hormone-stimulating test and brain computed tomography revealed panhypopituitarism with an empty sella. Glucocorticoid deficiency due to secondary hypoaldosteronism was thought to have caused the Na loss. She had been treated for thyroid dysfunction and hyperlipidemia with replacement of thyroid hormone and a lipid-lowering drug. Hyperlipidemia changed from type V into IIa in 4 yr. Furthermore, one of her brothers and one of her sons were suspected to have type IV hyperlipidemia. Familial combined hyperlipidemia accompanied by secondary hypothyroidism was thought to have increased the levels of both total cholesterol and triglyceride. Two renal biopsies in 3 yr showed lipid deposits in the mesangial cells and indicated a positive correlation between the levels of serum lipids and lipid deposits in glomeruli, which suggested an important role of abnormal lipid metabolism in the progression of glomerular lipidosis.<br>(Internal Medicine 31 : 44-49, 1992)
収録刊行物
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- Internal Medicine
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Internal Medicine 31 (1), 44-49, 1992
一般社団法人 日本内科学会