Feminizing Adrenocortical Carcinoma with Selective Suppression of Follicle-Stimulating Hormone Secretion and Disorganized Steroidogenesis: A Case Report and Literature Review
-
- Saito Takatoshi
- Division of Diabetes and Endocrinology, Department of Medicine, Jikei University School of Medicine, Japan
-
- Tojo Katsuyoshi
- Division of Diabetes and Endocrinology, Department of Medicine, Jikei University School of Medicine, Japan
-
- Furuta Nozomu
- Department of Urology, Jikei University School of Medicine, Japan
-
- Ono Katsuhiko
- Department of Pathology, Tohoku University School of Medicine, Japan
-
- Sasano Hironobu
- Department of Pathology, Tohoku University School of Medicine, Japan
-
- Utsunomiya Kazunori
- Division of Diabetes and Endocrinology, Department of Medicine, Jikei University School of Medicine, Japan
この論文をさがす
抄録
We report a 61-year-old male with gynecomastia, poor libido and erectile dysfunction. Endocrinological studies showed high levels of estradiol and dehydroepiandrosterone sulfate. Although luteinizing hormone (LH) level was within the normal limit, the concentration of follicle-stimulating hormone (FSH) was under the normal limit. Delayed response of LH and poor response of FSH to gonadotropin-releasing hormone administration were detected. Magnetic resonance imaging of the abdomen revealed a left adrenal tumor. Although the surgically-resected tumor was diagnosed as a high grade ACC based on Weiss's criteria of adrenocortical malignancy, no metastasis was detected. Since estrogen levels normalized after resection, feminizing ACC was confirmed. While LH concentration increased slightly after operation, FSH level became transiently elevated over the normal limit, and finally reached the normal range. These data may suggest that FSH was suppressed selectively by hormone produced by ACC different from estrogen.<br>
収録刊行物
-
- Internal Medicine
-
Internal Medicine 50 (13), 1419-1424, 2011
一般社団法人 日本内科学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679848313216
-
- NII論文ID
- 130000770519
-
- ISSN
- 13497235
- 09182918
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可