肺小細胞癌の外科治療：　術前化学療法と術後化学療法を中心に

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  • Surgical treatment for small cell lung cancer; possible advantage of preoperative chemotherapy.

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In 46 patients who underwent surgery at our facility between 1976 and 1991 the histological diagnosis was small cell carcinoma of the lung. The results of treatment were assessed retrospectively. The clinical stage was I in 19 Patients, II in 7, III in 15 and IV in 5. Preoperative chemotherapy was given to 17 patients and postoperative chemotherapy in 23. The 5-year survival rate was 29%, and the median survival time (MST) was 87 weeks in those who had lung resection. The 5-year survival rates was 39%, 40% and 29% for pathological stages I, II and III, respectively. The 5-year survival rate was 30% in the preoperative chemotherapy group and 32% in the postoperative chemothrapy group. In the preoperative chemotherapy group, the 5-year survival rate was as high as 80% for clinical stage I and II, but it was only 38% in the postoperative chemotheray group. The clinical stage and the pathological stage showed a high inconsitency rate of 45.7%, reflecting the presence of advanced stages in many patients. It was considered that preoperative chemotherapy is useful in the surgical treatment of small cell carcinoma of the lung, regardless of its stage.

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