かいよう性大腸炎患者の細胞性免疫能に関する研究

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  • Cellular immunological studies in patients with ulcerative colitis.

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The immune status of ulcerative colitis was investigated by a variety of tests in 62 patients of different clinical categories. The tests adopted were phytohemagglutinin (PHA) skin reactivity, peripheral lymphocytic transformation stimulated with PHA and concanavalin A (Con A), peripheral blood lymphocyte subpopulation (T cells, B cells and Ig G·FcR+ T cells) and T lymphocytes subsets detected by flow cytometry, using monoclonal antibodies ; OKT3, which detects all peripheral blood T lymphocytes ; OKT4 (T cells of helper-inducer phenotype); and OKT8 (T cells of suppressor-cytotoxic phenotype). Furthermore, inhibition activity of patient's serum (EAI), blocking rosette formation of peripheral lymphocyte to sensitized corpuscles (EA), was tested.<BR>The results were as follows. <BR>1) The PHA skin reactivity and the response of peripheral blood T cell to mitogen (PHA and Con A) diminished, suggesting a hyporeactive state of cell mediated immunity in ulcerative colitis. <BR>2) The percentages of OKT3 cells and OKT4 cells showed no significant change, but the percentages of OKT8 cells were reduced and the ratio of OKT4 to OKT8 T cells was elevated in the active stage. <BR>3) The levels of serum EAT, which is attributable to peripheral blood immune complexes, were high in ulcerative colitis. <BR>The percentages of Ig G Fc R+ T cells increased in ulcerative colitis. Judging form the response to mitogen stimulation, Ig G·Fc R+ T cells which increased in ulcerative colitis were mainly cytotoxic T lymphocytes, whereas those in colorectal carcinoma were suppressor T lymphocytes.

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