Study of Serum ELAM-1 (Endothelial Leukocyte Adhesion Molecule-1) in the Patients with Colon Cancer. Correlation with Metastasis.
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- Takahashi Y.
- Surgery of Cancer Reserch Institute Knazawa University
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- Watanabe M.
- Surgery of Cancer Reserch Institute Knazawa University
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- Masayoshi M.
- Surgery of Cancer Reserch Institute Knazawa University
Bibliographic Information
- Other Title
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- 大腸癌における血清Endothelial Leukocyte Adhesion Molecules (ELAM)‐1値との検討 とくに転移との相関
- Correlation with Metastasis
- とくに転移との相関
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Abstract
We studied a significance of serum ELAM-1 which was one of cell adhesion molecule and was known to bind a carbohydrate antigen sialyl Lewis X, in 30 patients with colon cancer. Serum level of ELAM-1 ranged from 23.8U/ml to 144.7U/ml with a meam of 66.1 ± 29.5 U /ml and normal value of ELAM-1 was calculated by mean + 2 SD of healthy human samples. Mean ELAM- 1 level was 87.0 ± 33.6 U / ml in patients with metastasis (Dukes C and D), which was significantly higer than in those without metastasis (Dukes A and B : 52.2±15.6U/ml). Sensitivity was 92.9 %, specificity was 93.8 % and accuracy was 93.3 % between positivity of serum ELAM-1 and metastasis, which was higher than those of CEA or CA19-9.<BR>Those results suggest that serum ELAM-1 would be a useful tumor marker as an evaluation of metastasis of colon cancer.
Journal
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- Nippon Daicho Komonbyo Gakkai Zasshi
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Nippon Daicho Komonbyo Gakkai Zasshi 47 (6), 515-518, 1994
The Japan Society of Coloproctology
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Details 詳細情報について
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- CRID
- 1390282679833153152
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- NII Article ID
- 130000783892
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- ISSN
- 18829619
- 00471801
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed