大腸ｓｍ癌の転移のリスクファクターに関する検討

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  • Histopathological Investigation of Risk Factors of Metastasis in Submucosal Invasive Carcinomas of the Colon and Rectum. Mainly Examining the Correlation Between the Degree of Invasion and Other Adverse Prognostic Factors.
  • Mainly Examining the Correlation Between the Degree of Invasion and Other Adverse Prognostic Factors

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We have investigated usefulness of our new classification of the degree of invasion as a landmark of outcome of patients with submucosal invasive colorectal carcinoma.<BR>We used the term "sm depth" to refer to vertical extension of carcinoma in the interstitium, defining "sm width" as horizontal extension of it. As a result of histopathological investigation of 14 cases of submucosal invasive carcinoma with metastasis and 158 cases without metastasis, our new classification showed good correlation with presence or absence of vascular invasion and metastasis, if it can be defined as minimal invasion (grade-1) when sm depth less than 500 micron and sm width less than 2mm, whereas as massive invasion (grade-III) when sm depth more than 1000 micron or sm width more than 4mm.<BR>In conclusion, our new, ;classification of the grade of invasion is significantly useful for decision about necessity of subsequent intestinal resection after endoscopic resection of colorectal submucosal invasive carcinoma.

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