Relationship between Serum Carotenoids and Hyperglycemia: A Population-based Cross-sectional Study.

• Suzuki Koji

  Department of Public Health, Fujita Health University School of Health Sciences

• Ito Yoshinori

  Department of Public Health, Fujita Health University School of Health Sciences

• Nakamura Sayuri

  Department of Adult Nursing, Fujita Health University School of Health Sciences

• Ochiai Junichi

  Department of Medical Electronics, Fujita Health University School of Health Sciences

• Aoki Kunio

  Aichi Cancer Center

抄録

The present study investigated the relationship between hyperglycemia and both serum carotenoids and intake of vegetables and fruits. Subjects with a history of diabetes mellitus (DM group, n=133) or with hyperglycemia diagnosed using a 5.6% cutoff value for hemoglobin Air (High HbAic group, n=151) were recruited from among inhabitants of a rural area in Hokkaido, Japan. Intake frequencies of vegetables and fruits were assessed using a questionnaire administered by public health nurses. Serum levels of carotenoids and retinol were measured using high-performance liquid chromatography. The relationships between high HbA1c or DM and both serum carotenoids and intake frequencies of vegetables and fruits were analyzed using logistic regression modeling for a case-control study; each case (High HbA1c or DM) was matched to two controls (healthy subjects without any history of disease) matched for sex and age (within 3 years). The odds ratio (OR) for high HbA1c was 0.49 (95% confidence interval: 0.29-0.85) on high intake frequency of carrot and pumpkin and the OR for DM was 1.21 (95% CI: 0.79-1.84). No significant relationships were observed between high HbAic and intake frequencies of other vegetables and fruits. The ORs on high serum levels of αand β-carotenes, lycopene, β-cryptoxanthin and zeaxanthin and lutein were 0.38 (0.22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively. In conclusion, intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia. J Epidemiol 2002;12:357-366.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｅｐｉｄｅｍｉｏｌｏｇｙ 12 (5), 357-366, 2002

  日本疫学会

キーワード

• intake of fruit and vegetables
• carotenoids
• beta-carotene
• hyperglycemia
• diabetes mellitus

詳細情報

• CRID: 1390282679452807808
• NII論文ID: 130000797626
• NII書誌ID: AA10952696
• DOI: 10.2188/jea.12.357
• COI: 1:STN:280:DC%2BD38njs1Gqsg%3D%3D
• ISSN: 13499092
• ISSN: 09175040
• PubMed: 12395879
• Web Site: https://www.jstage.jst.go.jp/article/jea1991/12/5/12_5_357/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003162303
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可