外リンパの高カリウム化によって惹起されるモルモット前庭神経核及び聴覚中枢路における糖消費量の変化について　オートラジオグラフィーを用いた研究

DOI PubMed 被引用文献1件

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タイトル別名
  • Changes of glucose uptake in vestibular and auditory nuclei induced by high perilymphatic potassium ion consentration. Autoradiographic study.
  • AUTORADIOGRAPHIC STUDY
  • オートラジオグラフィーを用いた研究

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Characteristic nystagmus could be provoked by introducing potassium ion into the unilateral perilymphatic space of healthy guinea pigs. At first, irritative nystagmus appeared for some time to the K+ introduced ear side, and then, it was followed by paralytic nystagmus which directed to the non introduced ear side.<br>During this experiment, the excitabilities of the vestibular nuclei and the central auditory nuclei were investigated by [14C] deoxyglucose method.<br>In the period of "irritative nystagmus", the increment of glucose uptake in the ipsilateral vestibular nucleus, especially in the superior, median and inferior part, was noticed more significantly than the contralateral vestibular nucleus. On the other hand, the period of "paralytic nystagmus" showed the significant increment of glucose uptake in all parts of the contralateral vestibular nucleus.<br>As to the excitability of the central auditory nuclei, the significant decrement of glucose uptake, which was noticed in all periods of this experiment, was predominant in the ipsilateral cochlear nucleus and other superior auditory nuclei of the contralateral side.

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