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- 加藤 明理
- 東邦大学医学部耳鼻咽喉科学第二講座
書誌事項
- タイトル別名
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- The difference between response of nasal mucosa to specific antigen and that to non-specific stimulus.
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抄録
To examine the difference between response of nasal mucosa to specific antigen and that to non-specific stimulus in the same patient, specific nasal provocation was performed using the house dust antigen disk while nasal respiratory resistance was continuously measured by Rhinograph. On the other hand, non-specific nasal provocation was performed with inhalation of methacholine while nasal respiratory resistance was continuously measured with Astograph. Thereafter the resulting response curves were analyzed. Subjects were 12 males and 9 females, who had nasal obstruction, watery rhinorrhoea and sneeze, and were proved to have allergic rhinitis by house dust.<br>To analyze specific response curve, primary nasal respiratory resistance (RrsN), reacting time (Ta) and slope signifying increase of nasal respiratory resistance (ORrsN) were used as parame-ters. To analyze non-specific response curve, primary nasal respiratory resistance (RrsNont), minimum dose of methacholine that caused an increase of nasal respiratory resistance (DminN)and slope signifying increase of nasal respiratory resistance (SdN) were used as parameters. Ta and DminN reflect sensitivity of nasal mucosa. Their values become smaller, it means sensitivity of nasal mucosa becomes higher. QRrsN and SdN reflect reactivity of nasal mucosa. Their values become larger, it means reactivity of nasal mucosa becomes larger. From the analysis of specific and non-specific response curves, value of Ta was smaller than that of DminN, and value of SdN was larger than that of ORrsN. These meant that nasal response was caused earlier in specific response curve than in non-specific one, and degree of nasal response was larger in non-specific response curve than in specific one.<br>From the above results, following conclusions were obtained.<br>1) Response of nasal mucosa to specific antigen is mainly composed of sensitivity of nasal mucosa.<br>2) Response of nasal mucosa to non-specific stimulus is mainly composed of reactivity of nasal mucosa.
収録刊行物
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- 日本耳鼻咽喉科学会会報
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日本耳鼻咽喉科学会会報 94 (7), 990-997, 1991
一般社団法人 日本耳鼻咽喉科頭頸部外科学会