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- 村上 匡孝
- 京都府立医科大学耳鼻咽喉科学教室
書誌事項
- タイトル別名
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- Study of the mechanism of supporting cells repairing the organ of corti in terms of cell kinetics. Nuclear DNA synthesis of supporting cell of the organ of Corti in the cochlea damaged by nitromin administration.
- NUCLEAR DNA SYNTHESIS OF SUPPORTING CELL OF THE ORGAN OF CORTI IN THE COCHLEA DAMAGED BY NITROMIN ADMINISTRATION
- 外有毛細胞障害蝸牛における支持細胞の核DNA合成から
抄録
3H-thymidine autoradiography in vivo was carried out on normal mature mice, whose organs of Corti were securely damaged by Nitrogen Mustard-N-oxide (nitromin). The cell kinetics of supporting cells of the organ of Corti were examined and relation between these changes and mechanism of supporting cells to maintain the organ of Corti was discussed in this paper.<br>A few grains in various kinds of supporting cells in S stage, which were not found in control mice without nitromin injection, were discovered. Those were detected in Hensen′s cell, Deiters′ cell, Claudius′ cells, and inner phalangeal cell. Mitosis was seen in one Claudius′ cell in addition. Therefore some supporting cells seem to be able to synthesize DNA and proliferate in the acutely damaged organ of Corti even in mature cochlea and those in G0 stage begin to go around cell cycle as occasion demands.<br>Although labelled supporting cells decreased over time, the portion of supporting cell is likely to change in proportion as the extension of damage in the organ of Corti. If this new dynamic change of cell kinetics in the acutely damaged organ of Corti means the reaction to repair the organ of Corti, the supporting cells seem to have a reasonable role to maintain the organ of Corti including repairment of reticular lamina.
収録刊行物
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- 日本耳鼻咽喉科学会会報
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日本耳鼻咽喉科学会会報 94 (3), 386-395, 1991
一般社団法人 日本耳鼻咽喉科頭頸部外科学会