Responsiveness of monkey skeletal muscle arteries to vasoconstrictor substances before and after cold storage.

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The stainless steel cannula inserting method was used to observe effects of α-adrenoceptor agonists, 5-HT and KCl before and after cold storage (3-5 days, at 4°C) in skeletal muscle branches of the simian deep femoral artery. Epinephrine (EPI), norepinephrine (NE), phenylephrine (PE), methoxamine (MT) and 5-hydroxytryptamine (5-HT) induced marked monophasic vasoconstrictions in a dose-dependent manner. 5-HT induced a greater vasoconstriction in larger diameter vessels (old animals) than that in smaller ones (young animals), suggesting age-related responses. A selective α2-stimulant, clonidine (CLO) or xylazine (XYL), produced only a slight vasoconstriction. Tyramine (TYR) also produced only a slight vasoconstrictor response. The order of potencies for inducing vasoconstrictions was EPI≥5-HT≥NE>MT=PE >> KCl>CLO=XYL=TYR. The vasoconstrictor responses to all used adrenergic agonists and 5-HT were not significantly influenced by the prolonged cold storage. However, KCl-induced constrictions were significantly suppressed by the cold storage. These results suggest that the postjunctional α-adrenoceptor in simian skeletal muscle arteries is mainly of the α1-type. Since cold storage caused a significant suppression of the KCl-induced response but not those of adrenoceptor agonists and 5-HT, it was considered that the mechanism of calcium entry to the vascular smooth muscle of skeletal muscle arteries might be significantly damaged by the cold storage.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 46 (3), 237-246, 1988

    公益社団法人 日本薬理学会

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