Effect of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) on the healing and hydrocortisone-induced relapse of acetic acid ulcers in rats with limited food-intake-time
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- ITO Mikio
- Department of Pharmacology, Faculty of Pharmacy, Meijo University
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- TANAKA Takao
- Department of Pharmacology, Faculty of Pharmacy, Meijo University
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- SUZUKI Yoshio
- Department of Pharmacology, Faculty of Pharmacy, Meijo University
書誌事項
- タイトル別名
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- Effect of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) on healing and hydrocortisone-induced relapse of acetic acid ulcers in rats with limited food-intake-time.
- Effect of N-(3-aminopropionyl)-l-histidinato zinc (Z-103) on healing and hydrocortisone-induced relapse of acetic acid ulcer in rats with limited-food-intake-time
- Effect on N-(3-aminopropionyl)-L-histidine zinc (Z-103) on healing and hydrocortisone-induced relapse of acetic acid ulcers in rats with limited food-intake-time
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抄録
In the healing test of acetic acid ulcers in rats with limited food-intaketime, Z-1 03 given, p.o., at doses of 3 and 10 mg/kg, twice a day, for 14 consecutive days from the day after acetic acid injection not only reduced the size and depth of the ulcers, but also promoted the regeneration of the defective mucosa. In the hydrocortisone-induced relapse test of acetic acid ulcers in rats with limited food-intake-time, Z-103 given, p.o., twice a day, at doses of 3 and 10 mg/kg for 20 consecutive days from the 40th day after the acid injection strongly prevented the exfoliation of the regenerated mucosa. Cimetidine (100 mg/kg × 2/day, p.o.), like Z-103, showed a marked relapse-preventive action in addition to the healing-promoting action. However, it was more effective on the healing. Gefarnate (300 mg/kg × 2/day, p.o.) markedly reduced the size and depth of the ulcers and strongly prevented the steroid-induced relapse, but showed no apparent effect on the regeneration of the defective mucosa. These results suggest that Z-103 may be a new therapeutic agent sharing both healing-promoting and relapse-preventive actions on gastric ulcers.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 52 (4), 513-521, 1990
公益社団法人 日本薬理学会