Prolonged inhibition of vasodilation and calcium influx by novel 1,4-dihydropyridine calcium antagonist FRC-8653

DOI PubMed 被引用文献10件
  • Yoshimoto Ryota
    Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc.
  • Dohmoto Hideki
    Life Science Laboratories, Central Research Laboratories, Ajinomoto Co., Inc.
  • Yamada Kaoru
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • Goto Atsuo
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo

書誌事項

タイトル別名
  • Prolonged Inhibition of Vascular Contraction and Calcium Influx by the Novel 1,4-Dihydropyridine Calcium Antagonist Cinaldipine (FRC-8653).

この論文をさがす

抄録

We examined the effects of FRC-8653, a novel dihydropyridine calcium antagonist, on the contraction of an arterial preparation and the calcium influx into vascular smooth muscle cells to clarify the long-lasting hypotensive activity of this drug. Inhibition by FRC-8653 persisted for more than 7 hr after its removal, whereas nifedipine and nicardipine exhibited shorter durations of suppressive activity. These results suggest that prolonged inhibition of calcium influx through L-channels contributes to the long-lasting vasodilative and antihypertensive activity of FRC-8653.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 56 (2), 225-229, 1991

    公益社団法人 日本薬理学会

被引用文献 (10)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ