The Iron Chelator Deferoxamine Prevents Cisplatin-Induced Lipid Peroxidation in Rat Kidney Cortical Slices.

• Kameyama Yoshiko

  Division of Pharmacology, Osaka University of Pharmaceutical Sciences

• Gemba Munekazu

  Division of Pharmacology, Osaka University of Pharmaceutical Sciences

抄録

We evaluated the effect of the iron chelator deferoxamine on lipid peroxidation produced by the nephrotoxic antineoplastic drug cisplatin in rat kidney cortical slices. The addition of deferoxamine to the incubation medium prevented such lipid peroxidation in the incubated slices. Treatment of rats with deferoxamine inhibited the increase in lipid peroxidation caused by cisplatin in the medium. These results suggest that iron may be a causal agent of cisplatin-induced lipid peroxidation.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 57 (2), 259-262, 1991

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390001204285300352
• NII論文ID: 130000833228
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.57.259
• COI: 1:CAS:528:DyaK3MXmslShsrg%3D
• ISSN: 13473506
• ISSN: 00215198
• ISSN: http://id.crossref.org/issn/00215198
• PubMed: 1812305
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819327337?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819327337?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1993076065
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可