CD47 regulates the TGF-β signaling pathway in osteoblasts and is distributed in Meckel's cartilage

DOI Web Site 参考文献34件
  • Shimada Koichi
    Department of Periodontology, Nihon University School of Dentistry Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry
  • Nakajima Akira
    Department of Orthodontics, Nihon University School of Dentistry Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry
  • Ikeda Kyoko
    Department of Periodontology, Nihon University School of Dentistry
  • Ishibashi Kazuya
    Department of Periodontology, Nihon University School of Dentistry
  • Shimizu Noriyoshi
    Department of Orthodontics, Nihon University School of Dentistry Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry
  • Ito Koichi
    Department of Periodontology, Nihon University School of Dentistry Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry

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  • CD47 regulates the TGF-.BETA. signaling pathway in osteoblasts and is distributed in Meckel's cartilage

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Previously, CD47 gene expression has been shown to increase during mandible development using a micro array technique. To determine the function of CD47 in osteoblasts, CD47 was silenced using siRNA in vitro. The TGF-β1 and phosphorylated-Smad2 levels and transcription factor genes related to bone metabolism increased dose-dependently with CD47 silencing. Furthermore, we determined the distribution of CD47 in mouse embryonic E13 and E15 in vivo. The CD47-positive cells were localized in Meckel's cartilage and antenatal mandibular bone. These results suggest that TGF-β1 signaling and mandible development might be regulated by CD47. (J Oral Sci 53, 169-175, 2011)

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