The Enhancing Effects of Amastatin, Phosphoramidon and Captopril on the Potency of [Met5]-Enkephal n in Rat Vas Deferens

• CUI Suying

  Department of Physiology, Institute of Clinical Research, China-Japan Friendship Heping North Street

• KAJIWARA Midori

  Department of Pharmacology, School of Medicine, Tokai University

• ISHII Kaori

  Department of Pharmacology, School of Medicine, Tokai University

• AOKI Kazuko

  Department of Pharmacology, School of Medicine, Tokai University

• SAKAMOTO Junshi

  Department of Pharmacology, School of Medicine, Tokai University

• MATSUMIYA Teruhiko

  Department of Pharmacology, School of Medicine, Tokai University

• OKA Tetsuo

  Department of Pharmacology, School of Medicine, Tokai University

書誌事項

タイトル別名

• The enhancing effects of amastatin, phosphoramidon and captopril on the potency of (Met5)-enkephalin in rat vas deferens.

抄録

The enkephalin-inactivating enzymes in rat vas deferens were studied by using the relatively specific inhibitor of each enzyme. The results showed that the rat vas deferens, like the other three preparations, guinea-pig ileum, mouse vas deferens and striatal membranes of guinea-pig brain, which had been investigated previously, contained three distinct enkephalin-hydrolyzing peptidases. Additionally, the enkephalin-hydrolyzing aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A in rat vas deferens were found to be inhibited maximally with 1 μ of amastatin, 1 μM of phosphoramidon and 1 μM of captopril, respectively. In contrast to these three enzymes, both L-tyrosyl-L-tyrosine-sensitive dipeptidyl aminopeptidase and D-phenylalanine-sensitive carboxypeptidase were suggested not to be involved significantly in the inactivation of exogenously given enkephalin in rat vas deferens. The characteristics of the enkephalin-degradative enzymes in rat vas deferens were discussed in terms of their similarities to and differences from those in the other preparations.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 42 (1), 43-49, 1986

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390001204289382784
• NII論文ID: 130000834467
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.42.43
• COI: 1:CAS:528:DyaL28XlsVKlsL0%3D
• ISSN: 13473506
• ISSN: 00215198
• PubMed: 3540390
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819378473?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819378473?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1987198777
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
  • CiNii Articles
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