Antidiuretic effects of alpha- and beta-adrenoceptor agonists microinjected into the hypothalamic paraventricular nucleus in water-loaded and ethanol-anesthetized rat

• TSUSHIMA Hiromi

  Department of Pharmacology, Nagoya City University Medical School

• MORI Mayumi

  Department of Pharmacology, Nagoya City University Medical School

• MATSUDA Tomohiro

  Department of Pharmacology, Nagoya City University Medical School

書誌事項

タイトル別名

• Antidiuretic effects of alpha- and beta-adrenoceptor agonists microinjected into the hypothalamic paraventricular nucleus in a water-loaded and ethanol-anesthetized rat.

抄録

Effects of catecholamines microinjected into the paraventricular nucleus in the hypothalamus on urine outflow in a rat which was loaded with water and anesthetized with ethanol were studied. L-Norepinephrine, L-epinephrine and L-isoproterenol induced potent antidiureses with similar time courses to each other. The ED50 values for L-norepinephrine, L-epinephrine and L-isoproterenol were approximately 5, 10 and 5 nmol, respectively. The D-isomer of isoproterenol demonstrated no significant antidiuretic activity. The effect of L-norepinephrine was inhibited strongly by premicroinjection of alpha- and beta-adrenoceptor antagonists. The effect of DL-isoproterenol was inhibited strongly by beta-adrenoceptor antagonists, but not affected by alpha-adrenoceptor antagonist. Premicroinjection of a muscarinic antagonist, atropine, partially inhibited anti-diuretic effects induced by L-norepinephrine and DL-isoproterenol. Visceral functions other than urine outflow such as mean blood pressure, respiration rate, heart rate and rectal temperature were not significantly altered when the urine outflow decreased down to 20-30% of the control by microinjection of L-norepinephrine and DL-isoproterenol. The results demonstrated that stimulation of alpha- and beta-adrenoceptor in the paraventricular nucleus induced potent antidiuretic effects, partial inhibition of which by atropine suggested a possible presynaptic facilitation of the release of ACh by the stimulation of the adrenoceptors.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 40 (2), 319-328, 1986

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390001204290449152
• NII論文ID: 130000834585
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.40.319
• COI: 1:CAS:528:DyaL28XhtVaqurg%3D
• ISSN: 13473506
• ISSN: 00215198
• PubMed: 2871211
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819379363?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819379363?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/1987012003
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • PubMed
  • CiNii Articles
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