Effects of Starvatin on Microsomal Cytochrome p-450 and Laurate-μ-hydroxylation of Rat Kidney and Liver

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  • HASUMURA Satoshi
    Department of Medicine, Tokyo Jikei University School of Medicine
  • ENDOW Hitoshi
    Department of Pharmacology, Faculty of Medicine, University of Tokyo
  • KAKUNO Katsuhiko
    Department of Pharmacology, School of Pharmacy, Hoshi University
  • HOJO Kazuo
    Department of Medicine, Nihon University School of Medicine
  • SAKAI Fuminori
    Department of Pharmacology, Faculty of Medicine, University of Tokyo

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タイトル別名
  • Effects of starvation on microsomal cytochrome P-450 and laurate-.OMEGA.-hydroxylation of rat kidney and liver.
  • Effects of Starvatin on Microsomal Cyto

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Cytochrome P-450 (P-450) content and laurate-ω-oxidation activity in rat kidney and liver microsomes were investigated following starvation. Multiple forms of P-450 were analyzed by one dimensional separation using peroxidase stained SDS-continuous gradient polyacrylamide gel electrophoresis. Gels of the hepatic microsomes treated with phenobarbital showed three P-450 bands, and the renal microsomes showed one sharp band, which was induced remarkably by starvation and coincided with the middle molecular form of P-450 from the hepatic microsomes. Since laurate-ω-oxidation activity was induced specifically by starvation but not by drug treatment, in both the kidney and the liver microsomes, the middle molecular form of P-450 might catalyze laurate-ω-oxidation. It seemed, therefore, that a special P-450 subunit catalyzing laurate-ω-oxidation has a greater function in the renal rather than hepatic microsomes because the specific laurate-ω-oxidation activity per starvation induced P-450 content was relatively similar in both the kidney and the liver.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 33 (5), 999-1006, 1983

    公益社団法人 日本薬理学会

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