Screening of host-mediaied antitumor polysaccharides by crossed Immunoelectrophoresis using fresh human serum

• SHIMURA Keishiro

  Institute of Laboratory Animals, Mie University School of Medicine

• ITO Hitoshi

  Department of Pharmacology, Mie University School of Medicine

• HIBASAMI Hiroshige

  Department of Biochemistry, Mie University School of Medicine

書誌事項

タイトル別名

• Screening of host-mediated antitumor polysaccharides by crossed immunoelectrophoresis using fresh human serum.
• Screening of Host Mediated Antitumor Po

抄録

On crossed immunoelectrophoresis, human serum C3 (the third component of complement) converted by antitumor polysaccharides (ATSO [antitumor polysaccharide oral], AB-P [Agaricaus blazei/polysaccharide], GU-P [Grifora umbellata polysaccharide], PS-K [polysaccharide Kureha] and zymosan) moved faster than native C3, appearing as the 3rd peak. The ratio of height of the 3rd peak to the α2-macroglobulin (α2-M) peak was linearly proportional to the dose of ATSO. At the dose of 500 μg/ml antitumor polysaccharides, the ratios were higher than 0.76, and the ratios for the serum treated with polysaccharide of no antitumor activity (dextran and gum arabic) were less than about 0.52. This ratio readily determined in vivo can be used as a measure for the antitumor activity of polysaccharides.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 33 (2), 403-408, 1983

  公益社団法人 日本薬理学会

キーワード

• Pharmacology

詳細情報

• CRID: 1390282679263053696
• NII論文ID: 130000835363
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.33.403
• COI: 1:CAS:528:DyaL3sXhvFWiu70%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 2627925
• PubMed: 6887647
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I2627925
• Web Site: https://search.jamas.or.jp/link/ui/1984109705
• 本文言語コード: en
• データソース種別:
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  • NDL
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• 抄録ライセンスフラグ: 使用不可