Increase in accumulation of L-poda(3,4-dihydroxyphenylalanine)in brain slices by alcohol

蟹池 健一, 吉田 博

doi:10.1254/jjp.13.292

Increase in accumulation of L-poda(3,4-dihydroxyphenylalanine)in brain slices by alcohol

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蟹池健一

Department of Pharmacology, Nara Medical College
吉田博

Department of Pharmacology, Faculty of Medicine, Osaka University

書誌事項

タイトル別名

INCREASE IN ACCUMULATION OF L-DOPA (3, 4-DIHYDROXYPHENYLALANINE) IN BRAIN SLICES BY ALCOHOL

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抄録

In our previous paper it was described that an amino acid, L-dopa (3, 4-dihydroxyphenylalanine) was accumulated in brain slices against concentration gradient and an energy dependent active transport process was assumed to be participated in this phenomenon (1, 4). The carrier system for this active transport of L-dopa was assumed to divide at least into two parts: a specific site to combine with L-dopa and the Na⁺, K⁺-activated ATP-ase which seems to play a common important role for many active transport processes. Moreover it was discussed on a role of intracellular K⁺ concentration in this active transport process (1-4).<BR> In this paper, effect of alcohol on accumulation of dopa in brain slices is examined, for alcohol is a typical neurotropic and lipotropic agent and it is assumed that alcohol may exert a certain influence on the phenomenon and it may be possible to get a clue to clarify a mode of action of alcohol on nervous system.