EFFECT OF LYONIOL-A ON DECEREBRATE RIGIDITY AND ELECTROENCEPHALOGRAM IN RATS

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  • FUKUDA Hideomi
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
  • WATANABE Kazuo
    Faculty of Pharmaceutical Sciences, Toyama University
  • ITO Tsugutaka
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University

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Lyoniol-A is a toxic component isolated from a poisonous tree in Japan (Lyonia ovalifolia var. elliptica). In our previous studies, it was shown in experimental animals that injection of lyoniol-A caused postures characterized by torsion, retrocollis, spasm and locomotive ataxia (1), and moreover it was suggested in the evoked electromyographic (EMG) study (2) that the sites of action involved the supraspinal and spinal structures.<BR> One of the interesting properties of lyoniol-A is that it causes remarkable locomotive ataxia. It was found in rabbits that administration of lyoniol-A for about 15 days caused a histological degeneration in certain nuclei of the extrapyramidal system (3). Since extrapyramidal nuclei are closely related to gamma-system, the effect of lyoniol-A on the intercollicular decerebrate rigidity mainly due to hyperactivity of gamma-efferent outflow from the brain (4) was examined. For comparison with lyoniol-A effects of chlorpromazine which markedly abolished the rigidity of this type (5), mephenesin (6, 7) and strychnine were studied.<BR> While analyzing the action of lyoniol-A in electroencephalographic (EEG) study, the compound was found to accelerate the arousal pattern in the motor cortex of curarized rats. For this reason, the effects of lyoniol-A on the cortical and subcortical EEG patterns in the encephale isole and cerveau isolé rats were examined. The stereochemical structure of lyoniol-A has been established (8) (Fig. 1).

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 22 (4), 457-465, 1972

    公益社団法人 日本薬理学会

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