Organic Hydroperoxide-Induced Activation of Liver Microsomal Glutathione S-Transferase of Rats In Vitro
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- Kunihara Mineo
- Department of Pharmacology, Tsukuba Research Laboratories, Upjohn Pharmaceuticals, Ltd.
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- Ohyama Miwako
- Department of Pharmacology, Tsukuba Research Laboratories, Upjohn Pharmaceuticals, Ltd.
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- Nakano Miyuki
- Department of Pharmacology, Tsukuba Research Laboratories, Upjohn Pharmaceuticals, Ltd.
書誌事項
- タイトル別名
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- Effects of Spiradoline Mesylate, a Selective .KAPPA.-Opioid-Receptor Agonist, on the Central Dopamine System with Relation to Mouse Locomotor Activity and Analgesia.
抄録
Neurochemical and behavioral investigations were made to assess the role of central dopaminergic systems in mouse locomotor activity and analgesia by spiradoline mesylate. Analgesic activities of the κ-opioid-receptor agonists spiradoline and U-50488H were not altered by haloperidol or L-dopa, whereas morphine analgesia was enhanced by haloperidol but attenuated by L-dopa. Spiradoline decreased spontaneous locomotor activity in mice and inhibited methamphetamine or morphine-induced locomotor activity. In contrast, morphine given alone increased locomotor activity and enhanced methamphetamine-induced locomotor activity. In a neurochemical study, spiradoline decreased the amounts of dopamine metabolites in the striatum, but did not alter them in the brainstem and cerebral cortex. Morphine increased the dopamine metabolite contents in all three brain regions tested. These results suggest that inhibition of the dopaminergic pathway in the brain by spiradoline may be involved in its suppression of locomotor activity, but not in its analgesia; whereas, stimulation of the dopaminergic pathway by morphine seems to function in both behaviors: enhancement of locomotor activity and inhibition of analgesia.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 62 (3), 223-230, 1993
公益社団法人 日本薬理学会