Involvement of Blood Glucose in the Dimethylthiourea-Induced Protection against Alloxan-Induced Diabetes.
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- Masukawa Tohru
- Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
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- Nakanishi Kunio
- Department of Clinical Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
抄録
Dimethylthiourea (DMTU, 4.0 mmol/kg) injected into mice 30 min prior to alloxan injection markedly protected mice against the diabetogenic actions of 75 mg/kg alloxan. At 30 min after the above dose of DMTU alone (no alloxan), there was a marked rise in blood glucose. Mannoheptulose, an antagonist of glucose action at pancreatic β-cells, when given 24 min after DMTU and 6 min before alloxan, eliminated the DMTU-induced protection. The protection was also removed in the fasted mice in which DMTU did not cause hyperglycemia. These results indicate that DMTU protected mice from alloxan-induced diabetes by the indirect mechanism of producing hyperglycemia at the time of alloxan injection.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 66 (1), 159-161, 1994
公益社団法人 日本薬理学会