Activin A and Superoxide Dismutase Synergistically Enhance Development of 1-Cell Mouse Embryos to the Blastocyst Stage In Vitro.
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- LU Rong Zhen
- Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
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- IKEDA Akihiko
- Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
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- TAKAHASHI Michio
- Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo
書誌事項
- タイトル別名
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- Activin A and Superoxide Dismutase Syne
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Supplementing Whitten's medium with both activin A and superoxide dismutase (SOD), either of which singly has a beneficial effect, can enhance synergistically the development of 1-cell mouse embryos to the blastocyst stage in vitro. To release the 2-cell block and support embryonic development up to blastocysts, the lowest concentrations were 1.0 ng/ml and 2.5 ng/ml of activin A in CD-1 and DBA/2NJcl mice, respectively, and 300IU/ml of SOD in both strains. The percent-age of cultured embryos developing from the pronuclear stage to the 3-or 4-cell stage was signifi-cantly higher in media containing both supplements at the concentrations mentioned above than in media supplemented with either activin A or SOD. Pronuclear embryos developed to either moru-lae or blastocysts in the activin A plus SOD group at significantly higher proportions (p<0.01) than those in groups treated with activin A or SOD separately. The synergism between the 2 supple-ments for releasing 2-cell block indicates that the modes of action are different for activin A and SOD.
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 40 (4), 279-284, 1994
公益社団法人 日本繁殖生物学会
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詳細情報
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- CRID
- 1390282681310139136
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- NII論文ID
- 130000846178
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- NII書誌ID
- AA10936678
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- COI
- 1:CAS:528:DyaK2MXkvF2lurg%3D
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- ISSN
- 13484400
- 09168818
- http://id.crossref.org/issn/09168818
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- NDL書誌ID
- 3602634
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可