農夫肺の免疫組織学的検討

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  • Immunohistologic studies on farmer's lung

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Immunologic studies on fifteen cases of farmer's lung, which were clinically and pathologically defined, were performed and the following results were obtained.<br>1) Nine of the 13 patients had clinical pictures of Arthus in type.<br>2) Precipitating antibodies against Micropolyspora faeni and/or Thermoactinomyces vulgaris were found in 14 out of 15 patients.<br>3) Five of the 12 patients had high levels of serum immune complexes.<br>4) Almost all the patients showed decreased cell-mediated hypersensitivity.<br>5) Only two out of 12 patients showed decreased levels of serum complement.<br>6) Alveolitis were found in all patients and granuloma were found in 10 out of 14 patients in histologic examination of the lung.<br>7) None of the patients showed depositions of immunoglobulin on capillary wall of the lung, but two cases showed depositions of complement along the blood vessels of the lung on immunofluorescence study.<br>8) The frequencies of HLA antigens of patients with farmer's lung were compared to these of the Japanese control, resulting in no statistically significant differences between them.<br>From these results, it was speculated that allergic reactions of both type III and type IV of Coombs and Gell's classification might perticipate in the development of farmer's lung.<br>HLA antigens specific to farmer's lung were not found out in Japanese patients with farmer's lung.

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