ストレプトゾトシン糖尿病ラットにおける二糖類水解酵素阻害剤ＡＯ‐１２８の改善作用

• 小高 裕之

  武田薬品工業株式会社研究開発本部生物研究所

• 松尾 隆夫

  武田薬品工業株式会社研究開発本部生物研究所

書誌事項

タイトル別名

• Ameliorating Effects of an Intestinal Disaccharidase Inhibitor, AO-128, in Streptozotocin-diabetic Rats.
• ストレプトゾトシン トウニョウビョウ ラット ニ オケル 2トウルイ スイカイ

抄録

The ameliorating activity of an intestinal disaccharidase inhibitor, AO-128, was evaluated in rats with diabetes of varying severity. Diabetic rats were produced by injecting 120mg/kg streptozotocin (STZ) into 1.5- and 5-day-old neonates. From the age of 9 week, the rats were given AO-128 as a dietary admixture at a dose of 5 mg/100g of diet for 28 days. AO-128 normalized the basal levels of plasma glucose, which were elevated, and both glucose tolerance and insulin response, which were impaired in animals injected with STZ at the age of 1.5 days. On the other hand, animals administered STZ at the age of 5 days showed overt diabetes syndrome including features such as hyperglycemia, hypoinsulinemia, hyperphagia, polydipsia, polyuria and glucosuria. AO-128 partly ameliorated these diabetic symptoms.

収録刊行物

• 日本栄養・食糧学会誌

  日本栄養・食糧学会誌 45 (1), 33-38, 1992

  公益社団法人 日本栄養・食糧学会

キーワード

• disacchardidase inhibitor
• streptozotocin diabetic rat
• glucose tolerance
• insulin response to glucose

詳細情報

• CRID: 1390001206291544832
• NII論文ID: 10009713114
• NII論文ID: 130000853413
• NII書誌ID: AN00311992
• DOI: 10.4327/jsnfs.45.33
• COI: 1:CAS:528:DyaK38Xks1aktrs%3D
• ISSN: 18832849
• ISSN: 02873516
• ISSN: http://id.crossref.org/issn/02873516
• NDL書誌ID: 3777010
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3777010
• Web Site: https://search.jamas.or.jp/link/ui/1994003062
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可