糸状菌の産生するカビ毒の変異原性と極微弱発光との関係について

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  • Detection of Mutagenic Activity of Mycotoxins by Salmonella typhimurium/microsome Assay and Ultra-weak Chemiluminescence.
  • シジョウキン ノ サンセイスル カビ ドク ノ ヘンイゲンセイ ト キョクビジ

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Twenty-one mycotoxins were examined for mutagenic potency in the Salmonella typhimurium microsome assay. Bisfuranoid mycotoxins such as afiatoxin B1 and G1, showed potent mutage- nicity, but B2 and sterigmatocystin showed weak mutagenicity. Aflatoxin G2, PR-toxin (an epoxide) and kojic acid gave negative results. Trichothecenes having an epoxide ring, such as T-2 toxin, nivalenol and fusarenon X, were also negative. The intensity of biochemiluminescence of the toxins by activation with S9 mix was also measured by a luminescence analyzer sensitive wavelengths of around 300-650nm (optimum 400nm). Significant emission was observed for bisfuranoid mycotoxins and PR-toxin in addition to cyclopiazonic acid (an indole). These results are nearly consistent with those obtained from bacterial assays.

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