Serum amphotericin B concentration in a very premature infant with disseminated candidiasis.
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- 韮沢 真理
- Department of Pediatrics, Nippon Kokan Hospital
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- 菅谷 憲夫
- Department of Pediatrics, Nippon Kokan Hospital
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- 三田村 敬子
- Department of Pediatrics, Nippon Kokan Hospital
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- 込山 貴子
- Department of Pediatrics, Nippon Kokan Hospital
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- 菊池 英之
- Department of Pediatrics, Nippon Kokan Hospital
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- 老川 忠雄
- Department of Pediatrics, School of Medicine, Keio University
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抄録
A 1, 040-g premature baby was diagnosed to have disseminated candidiasis and treated with amphotericin B (AMB) and 5-fluorocytosine. During the treatment, an unexpectedly large dose of AMB was infused unintentionally. AMB level was as high as 1.73 μg/mL soon after 5mg/kg infusion instead of 0.5mg/kg. However, it dropped rapidly to 0.83 μg/mL after 24 hours. AMB was detected in patient's serum at a higher level than minimal inhibitory concentration as long as one month after treatment was stopped. The patient showed liver dysfunction but no nephrotoxicity. The further studies are needed to establish safe and effective treatment regimen in premature infants with disseminated candidiasis.
収録刊行物
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- Ｔｈｅ Ｋｅｉｏ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ
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Ｔｈｅ Ｋｅｉｏ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ 38 (3), 319-324, 1989
The Keio Journal of Medicine