体質性黄疸と体質性ICG排泄異常症における血清胆汁酸の定量分析

DOI Web Site Web Site

書誌事項

タイトル別名
  • Serum Bile Acid Levels in Patients with Constitutional Hyperbilirubinemias and Constitutional ICG Excretory Defect
  • タイシツセイ オウソ ト タイシツセイ ICG ハイセツ イジョウショウ ニ

この論文をさがす

抄録

Fasting serum bile acid levels (FSBA) were determined by the gas-liquid chromatography in six patients with constitutional hyperbilirubinemias and in two patients with constitutional indocyanine green (ICG) excretory defect.<BR>FSBA revealed within normal range (0.60±0.53μg/ml n=9) in Gilbert's (G) syndrome, DubinJohnson (D-J) syndrome and constitutional ICG excretory defect, whereas FSBA were higher (3.07-4.74μg/ml) in Crigler-Najjar (C-N) syndrome Type II and Rotor's hyperbilirubinemia (R Type).<BR>Postprandial serum bile acid levels (PSBA) were measured at two hours following having of two eggs in each one patient with G syndrome, D-J syndrome, R Type and constitutional ICG excretory defect. PSBA was significantly increased in D-J syndrome and increasing rate was 136%.<BR>There were significant correlations between serum bile acid levels and serum bilirubin concentrations, ICG plasma disappearance rate, ICG plasma retention rate, BSP plasma disappearance rate and BSP plasma retention rate.<BR>From these results it was concluded that the hepatic transport of bile acids was specifically different in constitutional hyperbilirubinemias.

収録刊行物

  • 肝臓

    肝臓 19 (8), 770-778, 1978

    一般社団法人　日本肝臓学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ