アルコール性肝硬変に伴う肝性脳症に対するベンゾジアゼピンきっ抗薬の持続投与の効果

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  • The effect of a continuous administration of a benzodiazepine antagonist (flumazenil) to the hepatic encephalopathy in alcoholic liver cirrhosis

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To investigate the effect of flumazenil on the hepatic encephalopathy (HE) in patients with alcoholic liver cirrhosis, flumazenil was intravenously administered to five patients continuously for 3-6 days. Improvements of HE score were observed explicitly improved by more than grade II in all cases. Similarly, electroencephalogram (EEG) of patients were significantly altered from θ-δ wave or triphasic wave to slow α or α wave by flumazenil administration in all cases. Except a patient, HE scores were stable in two months after treatment. A continuous administration of flumazenil is therapeutically safe and useful to improve the HE in patient with alcoholic liver cirrhosis.

収録刊行物

  • 肝臓

    肝臓 44 (6), 283-289, 2003

    一般社団法人　日本肝臓学会

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