書誌事項
- タイトル別名
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- A case of drug-induced liver injury with positive LE phenomenon caused by mercazole
- メルカゾール ニ ヨリ ジャッキサレタ LE ゲンショウ ヨウセイ カン ショ
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A 38 year-old female patient with hyperthyroidism was treated with mercazole at a dose of 30mg per day. 15 days after starting therapy, Al-P, LAP and γ-GTP increased, and on the 20th day Al-P rose to 44K.A.U., LAP to 392 G.R.U. and γ-GTP to the extreme of 216mU, respectively. On the 25th day jaundice was observed and on the 50th day T-Bil rose to 37mg/dl. But transaminase was within the normal range throughout the treatment.<BR>The liver biopsy specimen showed marked cholestasis in the area of the central vein. Parenchymal change and cell infiltration in the portal tracts were slightly present.<BR>LE phenomenon on the 20th day and antinuclear antibody on the 27th day were seen to be positive, which was thought to be induced by mercazole.<BR>In addition, thiurazile also caused liver injury and the lymphocyte stimulation test was positive to both mercazole and thiurazile. From the view point of drug cross reaction, the existence of a thioamide radical seems to be important.<BR>These observations indicate a drug-induced intrahepatic cholestasis caused by mercazole.
収録刊行物
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- 肝臓
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肝臓 22 (10), 1453-1459, 1981
一般社団法人 日本肝臓学会
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詳細情報 詳細情報について
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- CRID
- 1390282679767501568
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- NII論文ID
- 10006807371
- 130000877114
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- NII書誌ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL書誌ID
- 2475302
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可